Diabetes Insipidus & SIADH

Ninja Nerds!

In this lecture, Professor Zach Murphy will present on Diabetes Insipidus (DI) and the Syndrome of Inappropriate Antidiuretic Hormone secretion (SIADH). We will discuss the pathophysiology of DI, which involves a deficiency of antidiuretic hormone (ADH) leading to excessive urine production, and SIADH, which involves excessive ADH leading to water retention and hyponatremia. The lecture will include a discussion on the clinical manifestations of DI, such as polyuria and polydipsia, and SIADH, such as fluid overload without edema and dilutional hyponatremia. The digital presentation will begin with the diagnostic approach, highlighting the importance of water deprivation tests for DI, serum, and urine osmolality measurements, and serum sodium levels. Finally, we will review management strategies for both conditions, emphasizing fluid intake adjustments and desmopressin for DI, and fluid restriction, salt tablets, or medications to block ADH effects in SIADH. Please support us below!

Table of Contents:

0:00 Lab

0:07 Diabetes Insipidus & SIADH Introduction

0:44 Pathophysiology of Diabetes Insipidus

4:29 Central Diabetes Insipidus

8:58 Nephrogenic Diabetes Insipidus

12:55 Pathophysiology of SIADH

20:41 Complications of Diabetes Insipidus

26:16 Complications of SIADH

32:51 Diagnostic Approach to Diabetes Insipidus

36:00 Diagnostic Approach to SIADH

38:14 Treatment of Diabetes Insipidus

39:24 Treatment of SIADH

45:05 Comment, Like, SUBSCRIBE!