Platelet Disorders

Ninja Nerds!

In this lecture, Professor Zach Murphy breaks down the essential concepts of Platelet Disorders, providing an in-depth review of the physiology, pathophysiology, and clinical relevance of these conditions. The lecture begins by exploring the origin, structure, and function of platelets in hemostasis, followed by a detailed discussion on quantitative and qualitative platelet disorders.

Topics include thrombocytopenia (with causes such as bone marrow failure, increased destruction, and sequestration), and thrombocytosis (both reactive and clonal), with a strong focus on the clinical implications and diagnostic approach. Zach also dives into immune thrombocytopenic purpura (ITP), thrombotic thrombocytopenic purpura (TTP), heparin-induced thrombocytopenia (HIT), and disseminated intravascular coagulation (DIC)—explaining their distinguishing features, lab findings, and treatments.

The lecture wraps up with a high-yield comparison of the most commonly tested platelet disorders on board exams, with real clinical pearls to help you master this material. Whether you’re preparing for the USMLE or sharpening your clinical knowledge, this video is packed with valuable content to solidify your understanding.

Enjoy the lecture!