Blood Transfusion

Ninja Nerds!

In this extensive lecture, Professor Zach Murphy delves into the topic of blood transfusions, starting with the basics of whole blood and breaking it down into its components like packed red blood cells (PRBCs), platelets, fresh frozen plasma (FFP), cryoprecipitate, and prothrombin complex concentrate (PCC). He explains in detail the indications for each type of blood product based on various clinical scenarios such as anemia, hemorrhagic shock, coagulopathies, and thrombocytopenia. The lecture then explores transfusion reactions, including febrile non-hemolytic reactions, hemolytic reactions (acute and delayed), allergic/anaphylactic reactions, transfusion-related acute lung injury (TRALI), and transfusion-associated circulatory overload (TACO). Finally, the video covers pre-transfusion testing processes, blood product modifications, and the proper response to transfusion reactions. Enjoy the lecture and support us below!

00:00 Lab

00:42 Types of Blood Products

02:06 Packed Red Blood Cells (PRBCs)

05:34 Fresh Frozen Plasma (FFP)

06:46 Platelet Transfusions

11:39 Cryoprecipitate and Prothrombin Complex Concentrate (PCC)

47:05 Managing DIC and Massive Bleeding

47:34 Cryoprecipitate and Its Uses

48:30 Blood Product Modifications: Irradiation

53:21 Leuko Reduction: Reducing White Blood Cells

57:56 Washing Blood Products: Reducing Proteins and Potassium

01:01:32 Pre-Transfusion Testing: Type and Screen vs. Type and Cross

01:14:24 Acute Transfusion Complications: Fever and Hemolysis

01:36:32 Managing Acute Hemolytic Reactions01:37:41 Understanding Allergic and Anaphylactic Reactions

01:53:43 Transfusion-Related Acute Lung Injury (TRALI)

02:04:24 Transfusion-Associated Circulatory Overload (TACO)

02:13:23 Massive Transfusion Protocols and Complications

02:21:10 Sequential Algorithm for Transfusion Needs