Pulmonary Hypertension

Ninja Nerds!

Professor Zach Murphy will be presenting on Pulmonary Artery Hypertension (PAH). We will be going into detail on the following main objectives:

1. Definition and Classification of Pulmonary Artery Hypertension

- Understand what pulmonary artery hypertension (PAH) is and how it differentiates from other types of hypertension.

- Familiarize yourself with the World Health Organization (WHO) functional classification system, which categorizes PAH based on symptom severity and limitations in daily activities.

2. Pathophysiology and Etiologies

- Delve into the underlying mechanisms that contribute to PAH, including vasoconstriction, vascular remodeling, and inflammation.

- Examine the role of various risk factors such as genetics, connective tissue diseases, and drug exposures in the onset and progression of PAH.

3. Clinical Manifestations and Presentation

- Learn to identify the common signs and symptoms associated with PAH, including but not limited to dyspnea, fatigue, and chest pain.

- Discuss the markers of disease severity and progression, such as exercise intolerance and the occurrence of syncope.

4. Diagnostic Criteria and Tools

- Understand the utility and interpretation of diagnostic tests like echocardiography, right heart catheterization, and pulmonary function tests.

- Familiarize yourself with the latest guidelines and consensus criteria for diagnosing PAH.

5. Initial Management Strategies

- Discuss evidence-based approaches for initial patient stabilization, focusing on pharmacotherapy with agents like endothelin receptor antagonists and phosphodiesterase-5 inhibitors.

- Understand the indications for supportive measures like oxygen therapy and diuretics.

6. Definitive Management Approaches

- Explore advanced treatment options such as prostacyclin analogs, soluble guanylate cyclase stimulators, and surgical interventions like lung transplantation.

- Evaluate the risks and benefits of each management strategy in light of the most current research and guidelines.

7. Complications and Prognosis

- Understand the potential complications of PAH, including right ventricular failure and arrhythmias.

- Discuss prognostic factors that can influence long-term outcomes, including WHO functional class, exercise capacity, and hemodynamic parameters.

Table of Contents:

0:00 Lab

0:07 Pulmonary Artery Hypertension (PAH) Introduction

0:37 Pathophysiology | Type I PAH

3:37 Pathophysiology | Type II PAH

5:39 Pathophysiology | Type III PAH

7:29 Pathophysiology | Type IV PAH

8:55 Complications | Right Heart Failure

13:17 Diagnostic Approach

17:26 Treatment

17:53 Vasodilator Therapy

19:52 Comment, Like, SUBSCRIBE!